Easy and Comprehensive Notes on Virology
|BY:- MUHAMMAD TALHA ANWAR
PMC ,FAISALABAD
SESSION 2013-2018
Virology
DNA ENVELOPED VIRUSES
1-Herpes Simplex
2-VZV
3-CMV
4-EBV
1-HERPES SIMPLEX VIRUS
LIFE CYCLE
Virus Binds to Cell using nectin and VP16———-> Virus Fuses With the
membrane———–> Capsid enters inside the Cell ———–>Now linear DNA and VP16
protein is inside the human Cell——–> Linear DNA is incorporated into Cell DNA while VP16
protein activates IE gene which form IE protein which in turn forms early protein like DNA
polymerase and Thymidine kinase———–>Cell in which Virus is present may undergo Lysis
by virus multiplication or may be in latent phase (mainly HSV 1 remains latent in Trigeminal
ganglion while HSV 2 in Lumbar and sacral Ganglion) ——–>Upon Any Stressful
conditions Cell may enter from latent to lytic phase .
MODE OF TRANSMISSION:-
Sexual Contact
Saliva
PATHOGENESIS:-
Trauma or Stressful conditions like radiation——–>Virus which used the
anterograde mechanism to travel towards ganglion now move back and can cause
vesicular skin lesions which contains Pus having viruses + Cellular Debris and lesions
also contains Multinucleated Giant Cells .
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