Contact USContact us

Easy and Comprehensive Notes on Virology

BY:- MUHAMMAD TALHA ANWAR

PMC ,FAISALABAD

SESSION 2013-2018

Virology

DNA ENVELOPED VIRUSES
1-Herpes Simplex
2-VZV
3-CMV
4-EBV

1-HERPES SIMPLEX VIRUS

LIFE CYCLE

Virus Binds to Cell using ​ ​ nectin and VP16———-> Virus Fuses With the

membrane———–> ​ Capsid enters inside the Cell ———–>Now linear DNA and VP16

​ protein is inside the human Cell——–> Linear DNA is incorporated into Cell DNA while VP16

protein activates ​ IE gene ​ which form ​ IE protein which in turn forms early protein like DNA

polymerase and Thymidine kinase———–>Cell in which Virus is present may undergo Lysis

by virus multiplication or may be in latent phase (mainly HSV 1 remains latent in Trigeminal

​ ganglion while HSV 2 in Lumbar and sacral Ganglion) ​ ——–>Upon Any Stressful

conditions Cell may enter from latent to lytic phase .

MODE OF TRANSMISSION:-

Sexual Contact

Saliva

​ PATHOGENESIS:-

Trauma or Stressful conditions like radiation——–>Virus which used the

anterograde mechanism to travel towards ganglion now move back and can cause

vesicular skin lesions which contains Pus having viruses + Cellular Debris and lesions

also contains Multinucleated Giant Cells .

 

Read and Download Complete Notes here

 

Speak Your Mind