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Chemotherapeutic Drugs ( Pharmacology of Chemotherapy) Important MCQ Points

Chemotherapeutic Drugs ( Pharmacology of Chemotherapy) Important MCQ Points. Chemotherapeutic Drugs and Cancer Chemotherapy is an important topic for Medical Students. To solve MCQs of UHS and other Universities in Professional exams,-just give a look to these points before going to exam.

Important MCQS of Chemotherapy Pharmacology

Drug of choice for syphilis… Benzathine penicillin G… Alternative tetracycline
For staph aureus sensitive … Methicilin naficilin oxacillin ( metjicilin not because of its nephrotoxicity) ….. Resistant to theses drugs…. MRSA… vancomycin….. Resistant to vancomycin VRSA….. Linezolid
Drug of choice for meningitis … Ceftriaxone
Drug of choice for gonorrhea …. iM ceftriaxone or cefixime oral …. Alternative is tetracycline or spectinomycin or ciprofloxacin oofloxacin
Aztreonam only effective against gram negative aerobs
Vancomycin effective against only gram positive organisms
Atypical bacteria chylamydia ricketsia mycoplasma…. DOC tetracycline
Ricketsia causes rocky mountain spotted fever ….. Tetracycline
Don’t use tetracycline with milk or antasids heavy ions bind to them
Drug of choice for corynobacterium diphtheria……. Erythromycin
Cholramphenicol causes …. Gray babybsyndrome ( absence of gucoronyl transferase) a plastic anemia (idiosynchriatic reaction)
Clindamycin causes pseudo membranous colitis…. To treat drug of choice is metronidazole and alternative is vancomycin oral
Aminoglycosides have oxygen dependant uptake so effective only against aerobs
Aminoglycosides have curare like effect (neuromuscular blocking) aminoglycosides are contraindicated with loop diuretics (ototoxicity)
Streptomycin .
.. TB tularemia bubonic plague
Doxycycline for Lyme’s disease
Sulphonamides most common adverse effect …. Hypersensitivity
Sulphonamides can cause crytalluria … Treated by busing excess of water
Cotrimoxazole… Combination of sulphamethoxazole and trimethoprim…. Drug of choice for toxoplasmosis and pneumocystis carni pneumonia …. Also used for respiratory and urinary tract infections
Drug of choice for typhoid ( salmonella) ciprofloxacin
Respiratory floroquinolones used for pneumonia ( third generation levofloxacin)
Cartilage abnormalities or tendon rupture by floroquinolones
Neomycin used for preparation of gut for abdominal surgery
Combination of drugs used in the treatment of TB … To prevent resistance
Isoniazid … Decreases vit B6 pyridoxine….. Peripheral neuropathy
Isoniazid and rifampin used for prophylaxis …. First choice isoniazid
Rifampin orange red coloured body secretions
Ethambutol …. Optic neuritis and red green color blindness
Pyrazinamide …. Polyarthralgias
Drug of choice for vaginal and esophageal candidiasis….. Fluconazole
Cryptococal meningitis ….. Fluconazole
Amphotericin B doc for coccidioides
Nephrotoxicity of amphotericin B can be minimized by using liposomal formulations
For nail fungal infections (onychomycosis) drug of choice terbibafine …. Squalene epoxidase inhibitor
For dermatophytes …. Griseofulvin….. Inhibits polymerization of microtubules
Nystatin …. Treatment of oral or mucosal candidiasis
Voriconazole …. Visual disturbances
Cytomegaolvirus retinitis ….. Ganciclovir
Herpes simplex virus …. Acyclovir
Acyclovir ….. Nephrotoxic
Needle stick injury of aids patient …. Zidovudine
Preg ant aids pt and to prevent vertical transmission ….. Zidovudine
Amantadine prevent uncoating of influenza virus by acting on M2 channels
For plasmodium vivax and vovale eradication ….. Primaquine ( tissue schizonticide)
For pasmodium falciparum sensitive…. Chloroquine …. For chloroquine resistant… Quinine or mefloquine…… For resistant to these drugs multi drug resistant falciparum …. Doxcycycline artemether
Prophylaxis ….. Placiparum sensitive …. Chloroquine….. resistant ….. Mefloquine…. Resistant ….. Doxycycline
Artemether not used for prophylaxis… Short duration
Halofentrine not used for prophylaxis …. QT interval prolongation
Black water fever …. Quinine
Giardiasis amebiasis trichomoniasis psudomembranous colitis and anaerobic bacteria….. Metronidazole
Leshminiasis …… Stibogluconate
Tape worms … Niclosamide
Round worms …. Albendazole
Anticancer should be done from Kaplan
Cyclophoshamide …. Hemorrhagic cystists … Use plenty of water
Doxyrubicin daunorunicin…. Cardiotoxic
Bleomycin busulfan….. Pulmonary fibrosis
Common adverse effects of anticancer drugs….. Alopecia stoamatis bone marrow suppression
Spindle poison …. Vincristine vinblastine ( vinka alkaloids)
Difference of cell cycle specific anticancer and cell cycle non specific anticancer should be done
Stages of cell cycle specific drugs should be remembered
Methotrexate toxicity minimized by leucovorin
Cyclophsophamide toxicity minimized by mesna