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Important Questions of Xenobiotics (Biochemistry) for 2nd year MBBS

       IMPORTANT QUESTIONS OF XENOBIOTICS

       SPECIFICATION   .5 SEQ / 3 MCQ

What are xenobiotics? how are they dealt within our body?

What is Tangier`s disease?

  1. a. What is biotranformation or detoxification
  2. b. Write the mechanism of Biotransformation or

Pathways

Guide line for mechanism & pathways

       Read, Phase 1 reactions like oxidation , reduction &

       hydroxylation & phase 2 reaction conjugation

  1. Write down the process of conjugation with four

         different examples SEE BELOW

  1. Write the process of oxidation & reduction with

     four examples

  1. Discuss the role of Cytochrome p450 in

         detoxification reactions

READ WITH THESE GUIDE LINES

Conjugation with glucuronic acid

Conjugation with glycine

Conjugation with glutamine

Conjugation with cystiene

TIP : Read the summary of Xenobiotics from Harper`s and you will be able to solve the SEQ and MCQs from this portion,