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UHS Patterned Important MCQs of Protein Metabolism for 2nd Year MBBS

                                       (Protein Metabolism)


  1. Positive nitrogen balance is seen in

(A) Starvation(B) Wasting diseases(C) Growing age(D) Intestinal malabsorption E None of them

2.All of the following are required for synthesis of glutamine except

(A) Glutamate(B) Ammonia(C) Pyridoxal phosphate(D) ATP (E) Glutamine synthase

3.Non-Protein amino acids are

(A) Ornithine(B) â-alanine(C) ã-amino butyric acid (D) Proline (E) All of them

4.Allosteric inhibitor of glutamate dehydrogenase is

(A) ATP (B) ADP(C) AMP (D) GMP E. None of them

5The amino acid that undergoes oxidative deamination at significant rate

(A) Alanine (B) Aspartate(C) Glutamate (D) Glutamine E. None of them

6.Methionine is synthesized in human body from

(A) Cysteine and homoserine(B) Homocysteine and serine(C) Cysteine and serine

(D) None of these E. All of them

7.Hydroxylation of phenylalanine requires all of the following except

(A) Phenylalanine hydroxylase (B) Tetrahydrobiopterin(C) NADH

(D) Molecular oxygen E. Phenylalanine

8.Free ammonia is released during

(A) Oxidative deamination of glutamate (B) Catabolism of purines(C) Catabolism of pyrimidine

(D) All of these E.) A & B both

  1. Ammonia is transported from muscles to liver mainly in the form of

(A) Free ammonia (B) Glutamine(C) Asparagine (C) Alanine( E) Beta alanine

  1. the fate of misfolding protein is
  2. A) may be reutilize B) destroy in Lysosomes C) may be required Ubiquitin Proteosomic proteolytic pathway D) all of them E) None of them

11.Urea cycle takes palace   in

(A) Cytosol (B) Mitochondria (C) Both (A) and (B) (D) None of these ( E).All of them

12.All of the following statements about phenylketonuria are correct except

(A) Phenylalanine cannot be converted into tyrosine (B) Urinary excretion of phenylpyruvate and

phenyllactate is increased (C) It can be controlled by giving a low phenylalanine diet

(D) It leads to decreased synthesis of thyroid hormones, catecholamines and melanin E. missing enzyme is Phenyl hydroxylase

13.Branched chain amino acids are

(A) Cysteine and cystine(B) Tyrosine and Tryptophan(C) Glycine and Serine

(D) Valine, Leucine and Isoleucine E. None of them

14.NH3 is detoxified in brain chiefly as

(A) Urea (B) Uric acid(C) Creatinine (D) Glutamine (E). GABA Neurotransmitter

15.Two nitrogen atoms of Urea in the urea cycle come from

(A) NH3 (B) One from NH3 and one from aspartate

(C) One from NH3 and one from glutamate (D) One from NH3 and one from alanine (E) All from   glutamine

16.Pyruvic acid can be obtained by transamination of alanine with

(A) á- keto glutaric acid(B) Acetoacetic acid(C) â OH butyric acid(D) Phosphoenol Pyruvic acid (E) None of them

17.All followings are ketogenic aminoacids except

(A) Leucine (B) Isoleucine(C) Phenyl alanine (D) Glycine (E) Tyrosine

18.Which amino acid is a lipotropic factor

(A) Lysine (B) Lecuine(C) Tryptophan (D) Methionine (E) All of them

 

  1. Regulator of Urea cycle is

(A) glutamine (B) N Acetyl Glutamine (C) Acetyl CoA (D) NAD+ (E) NADP

 

  1. Sulphur containing amino acids after catabolism produces a substance which

is excreted

(A) SO2 (B) HNO3 (C) H2SO4 (D) H2O2 (E) All of them

  1. The symptom of ammonia intoxication includes

(A) Blurring of vision (B) Constipation(C) Mental confusion (D) Diarrhoea (E) Insomania

22.Homogentisic oxidase is an

(A) Oxidase(B) Monooxygenase(C) Dioxygenase (D) Anaerotic dehydrogenase (E) All of them

23.Urea is produced physiologically by the action of the enzyme

(A) Urease (B) Glutaminase(C) Arginase (D) None of the above (E) all of them

  1. Enzyme deficient in Hyperammonemia type II is

(A) Glutamine synthetase(B) Glutaminase

(C) Ornithine transcarbamoylase(D) Carbamoylphosphate synthetase (E) Arginase

  1. 25. Uremia occurs in

(A)Cirrhosis of the liver(B) Nephritis(C) Diabetes mellitus(D) Coronary thrombosis E None of them

26.The transaminase activity needs the coenzyme:

(A) B1 (B) B6 – PO4(C) FAD+ (D) NAD+ E ) NADP

27.The integrator between the TCA cycle and urea cycle is

(A) Fumarate (B) Malate(C) Pyruvate (D) Citrate (E) none of them

28 From dietary protein as well as from the urea present in fluids secreted into the

gastrointestinal tract intestinal bacteria produce

(A) Carbondioxide(B) Ammonia(C) Ammonium sulphate D) Creatine E) A & B

29.A female neonate did well initially until approximately 24 hours of age when she became lethargic.A sepsis workup proved negative. At 56 hours, she started showing focal seizure activity. The plasma ammonia level was found to be (normal 5 to 50) Quantitative plasma amino acid levels revealed a marked elevation of argininosuccinate. These results supported the diagnosis of argininosuccinase deficiency. Which one of the following would be elevated in the serum of this patient, in addition to ammonia and argininosuccinate

  1. A. Asparagine B. Glutamine C. Lysine D. Urea E. Uric acid

30 Which one of the following statements concerning a one-week-old male infant with undetected classic phenylketonuria is correct?

  1. A. Tyrosine is a nonessential amino acid for the infant. B. High levels of phenylpyruvate appear in his urine.
  2. Therapy must begin within the first year of life. D. A diet devoid of phenylalanine should be initiated immediately E. When the infant reaches adulthood, it is recommended that diet therapy be discontinued

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