Important SEQs of Heme Metabolism with Answer keys for 1st year MBBS Students
Important SEQs of Heme Metabolism with Answer keys for 1st year MBBS Students
Note : For answer key of below given short essay questions check the download link at the end of the post .
Q1 a) Enumerate the Heme containing proteins other than hemoglobin
- b) Write down the biosynthesis steps of heme synthesis
Q2 a) Differentiate between the biochemical role of ALA synthase 1 & 2
- b) Write down the regulation of heme synthesis
Q3 a ClassifyPorphyrias
- b) Write down the enzyme deficient with associated clinical features of
Acute intermittent porphyria
Q4 a) Illustrate the process of degradation of Heme
- b) Discuss the biochemical basis of jaundice in new born
Q5 a) what is hyperbilirubinemia? Differentiate between uncojugated & conjugated
hyper bilirubinemia
- b) Explain briefly about the concept of direct & indirect bilirubin
Q6 a) Define and classify the Jaundice, Differentiate b/w Hepatic & Post hepatic jaundice
- b) Why excess bilirubin is deposited in eyes of jaundice patients
Q7 a) Enumerate normal Hemoglobin types & write down the significance of HbAIC
b).What is the biochemical cause of HbS & how would you diagnose the case?
Q8 a) Enlist causes of non hemolytic uncojugated hyperbilirubinemia
- b) Differentiate between Criglar Najjar syndrome type 1 & type 2
Q9 a) Describe Briefly the importance of glycosylated Hb (HbAIC)
- b) Why Brain is not damaged in adults due to unconjugated hyperbilirubinemia
Q10 A 6 month old infant presents to the paediatrician with complaints of painful hands and feet. On examination the chid is jaundiced and has an enlarged spleen. Complete Blood Count (CBC) shows a Hb of 5.2. Based on this clinical scenario, answer the following questions:
- a) What is the most likely diagnosis?
- b) How will the RBCs appear on peripheral blood smear exam?
- c) What is the test of choice to confirm diagnosis?
- d) What is the genetic basis of this disease?
- e) How will you treat the child?
Q 11. a. Give an illustrative diagrammatic view of complete degradation pathway
of heme in to bilirubin.
- Total serum bilirubin level of new born baby is highly increased up to 20mg that diffuses to the skin, eyes and other tissues; baby was immediately taken to the incubator for phototherapy
- What are the possible biochemical causes of jaundice in new born baby
ii Elaborate the mechanism of Phototherapy to decrease highly increased bilirubin in tissues
Q 12 What are the hall marks of obstructive jaundice
Q 13. Classify porphyrias ?give an overview of enzyme deficiency, Major sign
& symptoms & laboratory findings of all types of Porphyria
Q14. Out line the committed step of heme synthesis along with coenzyme & inhibitor of committed step
Q15. Define Porphyrias with their mode of genetic inheritance & their treatment
Q16 Define with causes & types of Jaundice
Q17. Name the drugs which increases the activity of ALA Synthase 2 in the liver
Q18. What is enzyme inducer give example with function?
Download Answer key
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